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目的：研究和探索不同蓝光照射方法治疗新生儿黄疸的临床疗效和不良反应。方法选择我院2014年11月~2015年11月接收的新生儿黄疸患儿130例，均为血清非结合胆红素增高病例，随机平均分组使用持续蓝光照射和间歇蓝光照射治疗患儿，对比和分析两组患儿临床治疗效果和不良反应发生率等。结果观察组患儿显效29例，临床治疗有效率为89.23%；对照组患儿显效26例，临床治疗有效率为87.69%。观察组患儿皮疹7例，发热4例，呕吐腹泻11例，临床不良反应发生率为33.85%；对照组患儿皮疹10例，发热6例，呕吐腹泻18例，临床不良反应发生率为52.31%。且P<0.05差异具有统计学意义，对比具有临床参考价值。结论间歇蓝光和持续蓝光照射治疗均能够明显地改善新生儿黄疸的临床症状，在临床治疗效果方面没有明显差异，但是间歇蓝光照射治疗能够明显地降低患儿临床不良反应的发生率，具有推广价值。“,”Objective To study and explore the clinical efficacy and adverse reactions of different blue light irradiation in the treatment of neonatal jaundice. Methods 130 cases of neonatal jaundice in our hospital from November 2014 to November 2015 were received, serum unconjugated bilirubin increased were randomly divided into two equal groups using continuous blue light and intermittent blue light irradiation in the treatment of children, comparison and analysis of two groups of clinical curative effect and adverse reaction rate. Results In the observation group, 29 cases were markedly effective, the effective rate was 89.23%; the control group was 26 cases, the effective rate was 87.69%. The observation group with 7 cases in 4 cases of skin rash, fever, vomiting and diarrhea in 11 cases, the clinical adverse reaction rate was 33.85%; 10 cases of the control group with 6 cases of fever, rash, vomiting and diarrhea in 18 cases, the clinical adverse reaction rate was 52.31%. And P<0.05 difference has statistical significance, compared with the clinical reference value. Conclusion The clinical symptoms of intermittent and continuous blue light blue light treatment can significantly improve the neonatal jaundice, there is no significant difference in clinical treatment, but the intermittent blue light treatment can significantly reduce the incidence of adverse reaction cases, has the value of popularization.