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目的：观察分析乙型肝炎病毒感染伴肝功能一样指标变化对孕妇早产发生的影响。方法回顾性分析我院2015年2月~2016年2月收治的120例肝功能异常的乙肝孕妇临床资料，测定孕妇的TBIL（总胆红素）、ALT（丙氨酸氨基转移酶）、AST（冬氨酸氨基转移酶）、TBA（血清胆汁酸）。结果对比早产孕妇和非早产孕妇的ALT、AST、TBA以及TBIL均数，早产组均高于非早产组，组间差异具有统计学意义（P<0.05）；当孕妇肝功发生异常，早产的发生率也随之提高，肝功中度以上的升高组，早产发生率显著高于轻度升高组，组间数据差异具有统计学意义（P<0.05）。结论乙型肝炎病毒感染晚期妊娠血清中ALT、AST、TBA、TBIL水平与早产的发生率密切相关。“,”Objective To observe and analyze the influence of hepatitis B virus infection with liver function index changes on the occurrence of preterm birth in pregnant women. Methods Clinical data of 120 cases of hepatitis B pregnant women with abnormal liver function and who accepted treatments in our hospital from February, 2015 to February, 2016 were retrospective analyzed,and the TBIL (total bilirubin), ALT (alanine aminotransferase), AST (alanine aminotransferase), TBA (serum bile acid) of pregnant women were determined. Results The ALT, AST, TBA, and TBIL were compared between preterm and non preterm pregnant women, the preterm group was higher than that in the non preterm group and the difference was statistically significant ( P<0.05);When the abnormal liver function of pregnant women, the incidence of preterm birth is increased,and the liver function were more than moderate level group.The incidence of preterm labor was significantly higher than that in the mild group, the difference was statistically significant ( P<0.05). Conclusion The levels of ALT, AST, TBA and TBIL in serum of patients with advanced hepatitis B virus infection are closely related to the incidence of premature labor.