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目的：通过检测强直性脊柱炎（AS）患者血清中TNF-α的表达水平，探讨其在AS发病中的临床意义。方法分别测定AS活动期患者、AS非活动期患者及健康人血清TNF-α、CRP、ESR水平。结果 AS活动期患者、AS非活动期患者血清TNF-α水平均显著高于健康人，其差异有统计学意义（P＜0.01）；AS活动期患者血清TNF-α水平显著高于AS非活动期患者，其差异有统计学意义（P＜0.05），且TNF-α的表达与CRP呈正相关，与ESR无明显相关性。结论 TNF-α是与AS发病相关的细胞因子，可作为AS的实验室诊断指标以及AS活动期临床疗效的监测指标。“,”Objective To discuss the clinical significance of TNF-α by detecting the expression of TNF-α in patients with ankylosing spondylitis. Methods The levels of serum TNF-α, CRP, ESR were determined respectively in the AS active patients, the AS inactive patients and the healthy people. Results The contents of TNF-α in the AS active patients and the AS inactive patients were obviously higher compared with healthy people with statistical significanc (P<0.01);TNF-α in the AS active patients were obviously higher than the AS inactive patients with statistical significanc (P<0.05);the expression of TNF-αand CRP were positively correlated, but no obvious correlated with ESR. Conclusion The TNF-αis a cytokine associated with the occurrence of the AS, and it can be used as the laboratory diagnosis indicators, as well as the monitoring indicator of clinical curative effect in AS activity.