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应用放射免疫法测定31例新生儿缺氧缺血性脑病(HIE)及12例正常新生儿血浆催乳素水平。结果显示,HIE患儿急性期血浆催乳素水平明显高于对照组(P<0.01)。中、重度HIE患儿急性期血浆催乳素水平显著高于恢复期(P均<0.01)。HIE惊厥组急性期血浆催乳素水平显著高于非惊厥组(P<0.01),恢复期则无显著差异。催乳素水平与惊厥发作持续时间呈正相关关系(r=0.482,P<0.05),但与惊厥类型无相关性。提示HIE患儿急性期血浆催乳素水平可作为判断病情与脑损伤严重程度及判断新生儿惊厥是否发作的一项参考指标。
Radioimmunoassay was used to determine plasma prolactin levels in 31 neonates with hypoxic-ischemic encephalopathy (HIE) and 12 normal neonates. The results showed that plasma levels of prolactin in children with HIE at acute stage were significantly higher than those in control group (P <0.01). Serum prolactin levels in acute and moderate HIE children were significantly higher than those in recovery (all P <0.01). In the HIE seizure group, the level of plasma prolactin in the acute phase was significantly higher than that in the non-convulsion group (P <0.01), while there was no significant difference in the recovery period. The level of prolactin was positively correlated with the duration of seizure (r = 0.482, P <0.05), but no correlation with seizure type. It suggests that the level of plasma prolactin in acute stage of HIE may be used as a reference index to judge the severity of the disease and brain injury and to determine whether the onset of seizures in newborns.