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目的探讨米索前列醇不同给药方式用于瘢痕子宫中期妊娠引产的有效性和安全性。方法 120例自愿要求终止妊娠既往有剖宫产史的孕14～20周妇女,随机分为两组。A组60例在口服米非司酮2天后,口服米索前列醇0.2mg及阴道后穹隆放置0.4mg,若无规律宫缩出现则每3～4h口服米索0.2mg。B组60例在口服米非司酮2天后阴道后穹隆放置米索0.6mg,6h后无规律宫缩者阴道后穹隆再放置0.4～0.6mg,总量不超过1.2mg。结果 A组从开始用药至分娩的平均时间较B组明显缩短(P<0.05),A组总有效率100%,B组总有效率93%(P<0.05)。结论米索前列醇口服加阴道后穹隆放置用于瘢痕子宫中期妊娠引产疗效显著,是一种安全、有效、方便的方法,且效果优于单纯阴道放置。
Objective To investigate the efficacy and safety of misoprostol in different modes of delivery for induction of labor induced by scar pregnancy. Methods A total of 120 women aged 14 to 20 weeks who voluntarily requested termination of pregnancy with a history of cesarean section were randomly divided into two groups. A group of 60 patients after oral administration of mifepristone 2 days, oral misoprostol 0.2mg and vaginal fornix placed 0.4mg, if there is no regular contractions occur every 3 ~ 4h oral misoprostol 0.2mg. Group B, 60 cases of oral administration of mifepristone 2 days after vaginal fornix placed 0.6 mg misoprostol, irregular contractions after 6 h vaginal fornix and then placed 0.4 ~ 0.6mg, the total does not exceed 1.2mg. Results The average time from the beginning of medication to delivery in group A was significantly shorter than that in group B (P <0.05). The total effective rate was 100% in group A and 93% in group B (P <0.05). Conclusion Ovrosoprostenol oral plus vaginal fornix placed for scar pregnancy in the second trimester pregnancy induction of significant effect is a safe, effective and convenient method, and the effect is better than simple vaginal placement.