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大肠癌早期缺乏特异性症状,临床所见多数已数中晚期。5-氟尿嘧啶(5-Fu)是治疗大肠癌最常用的药物,但客观有效率低,对延长生存裨益不大,且5-Fu治疗失败后,缺乏有效的二线药物。郑州市第九人民医院于2006年9月—2009年9月应用开普拓(Campto,CPT-11)联合5-氟尿嘧啶(5-FU)与亚叶酸钙(CF)治疗晚期大肠癌32例,疗效肯定,不良反应降低,现报告如下:
Early lack of specific symptoms of colorectal cancer, most of the clinical findings have been in the number of late. 5-Fluorouracil (5-Fu) is the most commonly used drug for the treatment of colorectal cancer. However, its objective and low efficiency is not good for prolonging survival. After 5-Fu treatment fails, there is a lack of effective second-line drugs. Ninth People’s Hospital of Zhengzhou City, from September 2006 to September 2009, 32 patients with advanced colorectal cancer were treated with Campto (CPT-11) combined with 5-fluorouracil (5-FU) and leucovorin (CF) Positive effect, reduce adverse reactions, are as follows: