Glioblastoma-derived tumor cells induce vasculogenic mimicry through Flk-1 protein activation

• 作 者: Francescone R Scully S Bentley B Yan W Taylor SL Oh D Moral L Shao R
• 机 构: Molecular and Cellular Biology Program,Morrill Science Center,University of Massachusetts,
• 出 处: 中国神经肿瘤杂志
• 发表日期: 2013年03期
• 关键词: microvascular malignancy extremely pathogenesis aggressive essentially angiogene

Glioblastoma(GBM)is extremely aggressive and essentially incurable.Its malignancy is characterized by vigorous microvascular proliferations.Recent evidence has shown that tumor cells display the ability to drive blood-perfused vasculogenic mimicry(VM),an alternative microvascular circulation independent of endothelial cell angiogenesis.However,molecular mechanisms underlying this vascular pathogenesis

It is malignancy is characterized by vigorous microvascular proliferations. It has shown that tumor cells display the ability to drive blood-perfused vasculogenic mimicry (VM), an alternative microvascular circulation independent of endothelial cell angiogenesis .However, molecular mechanisms underlying this vascular pathogenesis