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目的 观察中西医结合疗法对消化性溃疡 (PU)的疗效及胃粘膜保护作用。方法 采用前瞻性、随机双盲、安慰剂对照研究 ,93例Hp阳性PU被随机分为 4组。A组 (新三联 ) :兰索拉唑 (达克普隆 ) +阿莫西林 +克拉霉素 ;B组 (灭Hp胶囊四联 ) :新三联 +灭Hp胶囊 ;C组 (灭Hp胶囊三联 ) :兰索拉唑 +克拉霉素+灭Hp胶囊 ;D组 (安慰剂 ) :胃舒平。双盲双模拟用药。治疗前及治疗后 4周复查胃镜 ,并检测胃粘膜磷脂、氨基己糖和血清表皮生长因子 (EGF)。结果 Hp根治率B、C组与A组分别为 96 4%、 92 0 %和 92 0 % ;溃疡愈合率分别为 10 0 0 %、 92 0 %和 88 0 % ,三组间差异无显著性 ,明显高于D组 (分别 0 0 % ,2 0 0 % ) (均P <0 0 5 )。B、C组胃粘膜磷脂、氨基己糖和血清EGF含量治疗后明显高于治疗前 (均P <0 0 5 )。A组仅氨基已糖较治疗前升高 ,D组磷脂、氨基己糖和EGF治疗后较治疗前无明显变化 (P >0 0 5 )。结论 灭Hp胶囊三、四联疗法具有高效的Hp根除、溃疡愈合及胃粘膜保护作用。
Objective To observe the curative effect of traditional Chinese and western medicine on peptic ulcer (PU) and the protective effect of gastric mucosa. Methods A prospective, randomized, double-blind, placebo-controlled study was conducted. Ninety-three Hp-positive PUs were randomly divided into four groups. Group A (new triple): Lansoprazole (daclopronide) + amoxicillin + clarithromycin; Group B (off Hp capsule quadruple): new triple + off Hp capsule; C group (off Hp capsule triple ): Lansoprazole + Clarithromycin + Off Hp capsule; Group D (placebo): Stomach Shuping. Double-blind double-dummy medication. Gastroscopy was performed before treatment and 4 weeks after treatment, and gastric mucosal phospholipids, hexosamine and serum epidermal growth factor (EGF) were detected. Results The cure rate of Hp was 96 4%, 92 0% and 92 0% respectively in group B, 100%, 92 0% and 88 0% respectively. There was no significant difference between the three groups , Which was significantly higher than that in group D (0% and 200% respectively) (all P <0 05). The gastric mucosal phospholipid, hexosamine and serum EGF levels in group B and group C were significantly higher than those before treatment (all P <0.05). Group A only aminohexose increased before treatment, group D phospholipid, hexose and EGF after treatment than before treatment no significant change (P gt; 0 05). Conclusion Off Hp capsule triple therapy with efficient Hp eradication, ulcer healing and gastric mucosal protection.