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复发性阿弗它性溃疡(Recurrent Aphthous Ulcer,RAU)指具有周期性复发特征的口腔粘膜溃疡,普遍将其归入自身免疫或胶原性疾病范畴,病因与病机均不甚明确,但有明显的遗传倾向。该病组织学上表现为上皮局限性水肿与坏死,上皮内微血管内皮细胞肿胀致管腔变窄及血栓形成,颇类似于血栓性微血管炎症导致的局限性组织坏死与溃疡。60年代末Davis E.等人曾发现该病的复杂型——白塞氏综合征(Behcet's Syndrome)患者的舌尖粘膜微循环有明显异常,表现为菌状乳头减少甚至消失。后来,Maciejewski W.等人
Recurrent aphthous ulcer (RAU) refers to the characteristics of recurrent oral mucosal ulcers, generally classified as autoimmune or collagen disease, the etiology and pathogenesis are not clear, but there is obvious Genetic predisposition The disease is histologically characterized by localized edema and necrosis of the epithelium, narrowing of the lumen and thrombosis of the lumen with intraepithelial capillary endothelial cell swelling, and is quite similar to the localized tissue necrosis and ulceration caused by thrombotic microvascular inflammation. In the late 1960s, Davis E. et al. Found that there was a significant abnormality in the microcirculation of the tongue of the tongue in patients with Behcet's Syndrome. The appearance of the papillary papilloma was reduced or even disappeared. Later, Maciejewski W. et al