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目的探讨2型糖尿病患者(T2DM)和糖调节受损(IGR)患者血清烟酰胺磷酸核糖转移酶(Nampt)的特征及其与肿瘤坏死因子α(TNFα)的关系。方法入选本院内分泌科连续6个月间新诊断尚未接受降糖药物治疗的70例T2DM患者、42例IGR患者,测定并分析血清Nampt和TNFα水平与54例健康对照者的差异,分析各组血清Nampt水平与TNFα、人体测量参数和代谢参数之间的关系。结果血清Nampt和TNFα水平在T2DM组、IGR组与健康对照组的差异无统计学意义;Nampt水平在T2DM非肥胖亚组高于健康对照非肥胖亚组(P<0.05),在IGR和健康对照腹型肥胖亚组高于对应非腹型肥胖亚组(P均<0.05),在T2DM和IGR总组与TNFα无线性相关,在IGR和健康对照腹型肥胖亚组则与TNFα呈线性负相关(P<0.05,P<0.01),在IGR总组、IGR和T2DM非腹型肥胖亚组与糖化血红蛋白线性正相关(分别为P<0.01,P<0.05和P<0.05)。结论初发T2DM患者、IGR患者血清Nampt和TNFα与健康者无差异。非肥胖糖代谢紊乱者血清Nampt水平与糖化血红蛋白正相关;不伴或伴有轻度糖代谢紊乱的腹型肥胖者血清Nampt水平与TNFα水平负相关。
Objective To investigate the characteristics of serum niacinamide phosphoribosyltransferase (Nampt) in patients with type 2 diabetes mellitus (T2DM) and impaired glucose regulation (IGR) and its relationship with tumor necrosis factor α (TNFα). Methods A total of 70 T2DM patients and 42 IGR patients newly diagnosed with hypoglycemic agents were enrolled in the Department of Endocrinology of our hospital for 6 months. The differences of serum Nampt and TNFα levels and 54 healthy controls were analyzed and analyzed. The relationship between serum Nampt levels and TNFα, anthropometric parameters, and metabolic parameters. Results There was no significant difference in serum Nampt and TNFα levels between T2DM group and IGR group and healthy control group. The level of Nampt in T2DM non-obese subgroup was higher than that in healthy non-obese subgroup (P <0.05) The abdominal obesity subgroup was higher than the corresponding non-abdominal obesity subgroup (P <0.05), but there was no linear correlation between TNFα and total adiponectin in T2DM and IGR groups, but negatively correlated with TNFα in IGR and healthy abdominal obesity subgroups (P <0.05, P <0.01). There was a linear positive correlation between non-abdominal obesity subgroup of IGR and T2DM and glycosylated hemoglobin (P <0.01, P <0.05 and P <0.05, respectively) Conclusions There is no difference in the serum levels of Nampt and TNFα between IGR and healthy subjects in newly diagnosed T2DM patients. Serum Nampt levels in non-obese glucose metabolism disorders were positively correlated with HbA1c levels; serum Nampt levels in abdominal obesity patients with or without mild glucose metabolism were negatively correlated with TNFa levels.