论文部分内容阅读
1 丙型肝炎与艾滋病混合感染特点全球丙型肝炎病毒(HCV)感染者约2亿;艾滋病毒(HIV)感染者约3500万。在 HIV 感染者中约1/3混合 HCV感染。混合 HCV、HIV 感染途径以不洁输血和静脉药瘾传播为主。一般先感染 HIV,80％的 HCV 感染者发生在吸毒(静脉药瘾)的第一年。容易合并或先后感染的原因与该2种病毒的传播途径一致有关;2种病毒都是高变异病毒,而 HCV 变异频率比 HIV 更强,因此很容易逃逸人体免疫系统的追击。混合感染者较单独 HCV 感染者的毒株具有更强的传染性。已发现混合感染者中,HCV RNA 的拷贝数特别高,对性伙
1 Hepatitis C and HIV co-infection Features About 200 million people are infected with the global Hepatitis C virus (HCV); and about 35 million people are living with HIV. Approximately 1/3 of HCV infections are mixed in HIV-infected individuals. Mixed HCV, HIV infection pathways with unclean blood transfusion and intravenous drug addiction based. HIV is generally first infected, and 80% of HCV infections occur in the first year of drug addiction (IV drug addiction). The reasons for the easy merger or subsequent infection are consistent with the transmission routes of the two viruses. Both viruses are highly variant viruses, and the frequency of HCV mutation is stronger than that of HIV, so it is easy to escape the chase of the human immune system. Mixed infections are more infectious than those infected with HCV alone. Among co-infected patients, HCV RNA has been found to have particularly high copy numbers for sexual partners