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甲硝唑是抗厌氧菌的首选药物,在临床应用中,常需和其它药物混合静滴,本文就甲硝唑与青霉素类、头孢菌素类、大环内酯类、氨基糖苷类、林可胺类、氯霉素类、喹诺酮类抗生素以及抗肿瘤抗生素混合静滴的可行性及配伍液的稳定性做一简要综述。1 青霉素类1.1 青霉素 G 钠与甲硝唑葡萄糖注射液(pH4.8)配伍,青霉素4h 效价可维持在95%,甲硝唑在24h 内稳定,因此青霉素加到甲硝唑葡萄糖注射液中,4h 内滴完是可行的。但是甲硝唑注射液与青霉素 G 钾配伍,混合液的 pH 值随贮放时间延长而不断变化,不宜配伍使用。
Metronidazole is the preferred anti-anaerobic drugs, in clinical applications, often mixed with other drugs intravenous infusion, metronidazole and penicillins, cephalosporins, macrolides, aminoglycosides, Lincosamine Class, chloramphenicol, quinolone antibiotics and antitumor antibiotics intravenous infusion of the feasibility and stability of the compatibility of a brief review. 1 Penicillin 1.1 Penicillin G sodium and metronidazole glucose injection (pH4.8) compatibility, penicillin 4h titer can be maintained at 95%, metronidazole stable within 24h, so penicillin added to metronidazole glucose injection , 4h drop end is feasible. However, metronidazole injection and penicillin G potassium compatibility, the pH value of the mixture with the storage time and changing, should not be used in compatibility.