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目的探讨维生素A联合补铁治疗学龄前儿童贫血的临床应用效果。方法选择2012年10月—2014年10收治的学龄前维生素A缺乏(vitamin A deficiency,VAD)或(和)铁缺乏(Iron deficiency,ID)儿童200例作为研究对象,随机分为对照组和观察组各100例。对照组给予补铁治疗,观察组在对照组基础上联合补充维生素A治疗。观察并比较两组Hb、血清维生素A、血清铁浓度(serun iron,SI)的变化情况,治疗前后免疫功能变化情况及消瘦、生长迟缓发生情况。计量资料组间比较采用t检验,组内比较采用配对t检验,计数资料采用χ2检验及Fisher确切概率法检验,P<0.05为差异有统计学意义。结果观察组Hb、维生素A、SI水平分别为(139.67±7.62)g/L、(0.89±0.29)、(17.22±5.93)μmol/L,均显著高于对照组的(126.64±4.20)g/L、(0.76±0.31)、(13.97±3.86)μmol/L,差异均有统计学意义(均P<0.05)。观察组治疗后lg A水平为(2 105.46±442.64)mg/L,显著低于对照组的(2 543.61±385.27)mg/L,观察组Ig G、IL-2水平分别为(7.68±1.22)g/L、(271.43±85.34)ng/L,显著高于对照组的(7.21±1.53)g/L、(190.16±75.64)ng/L,差异均有统计学意义(均P<0.05)。结论维生素A联合补铁治疗学龄前儿童贫血能够改善营养缺乏现象,提高机体免疫力。
Objective To investigate the clinical effect of vitamin A combined with iron therapy on anemia in preschool children. Methods 200 children with preschool-age vitamin A deficiency (VAD) or (and) iron deficiency (ID) admitted to our hospital from October 2012 to 2014 were randomly divided into control group and observation group Group of 100 cases. The control group was treated with iron supplementation. The observation group was treated with vitamin A supplementation on the basis of the control group. The changes of Hb, serum vitamin A, serum iron concentration (SI), immune function before and after treatment and the incidence of emaciation and growth retardation were observed and compared. Measurement data were compared between groups using t test, the group was compared using paired t test, count data using the χ2 test and Fisher exact test, P <0.05 was considered statistically significant. Results The levels of Hb, vitamin A and SI in the observation group were (139.67 ± 7.62) g / L and (0.89 ± 0.29) and (17.22 ± 5.93) μmol / L respectively, which were significantly higher than those in the control group (126.64 ± 4.20 g / L, (0.76 ± 0.31) and (13.97 ± 3.86) μmol / L, respectively (all P <0.05). The level of IgA and IL-2 in observation group was (2 105.46 ± 442.64) mg / L, which was significantly lower than that in control group (2. 543.61 ± 385.27) mg / (271.43 ± 85.34) ng / L, which was significantly higher than that of the control group (7.21 ± 1.53 g / L, 190.16 ± 75.64 ng / L, all P <0.05). Conclusion The combination of vitamin A and iron supplementation in the treatment of anemia in preschool children can improve nutritional deficiencies and improve immunity.