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目的:探究板蓝根联合阿奇霉素对小儿支原体肺炎患者血清中TNF-α、IL-6、IL-8和IL-10浓度的影响。方法:选择2014年1月-2014年12月在我院接受治疗的患儿80例,均确诊为支原体肺炎,按随机数字表分为实验组和对照组。对照组给予阿奇霉素粉针剂与阿奇霉素治疗。实验组在对照组基础上给予板蓝根提取液治疗。观察并比较两组治疗前后外周血TNF-α,IL-6,IL-8及IL-10水平的变化情况及疗效与不良反应发生率。结果:实验组的临床治疗的总有效率较高(P<0.05);治疗后两组促炎因子TNF-α、IL-6、IL-8水平均明显下降(P<0.05),与对照组相比,实验组TNF-α、IL-6、IL-8水平较低(P<0.05);治疗后两组患儿血清抗炎因子IL-10水平均下降(P<0.05),与对照组相比,实验组IL-10较低(P<0.05);与对照组相比,实验组不良反应发生率较低(P<0.05)。结论:板蓝根联合阿奇霉素能够明显降低小儿支原体肺炎患者血清中TNF-α、IL-6、IL-8和IL-10的浓度,提高治疗效果,对临床有指导意义。
Objective: To investigate the effect of Radix isatidis combined with azithromycin on the serum levels of TNF-α, IL-6, IL-8 and IL-10 in children with mycoplasma pneumonia. Methods: From January 2014 to December 2014, 80 children were treated in our hospital. All patients were diagnosed as Mycoplasma pneumonia. According to the random number table, they were divided into experimental group and control group. The control group was treated with azithromycin and azithromycin. The experimental group was given Radix isatidis extract on the basis of the control group. The changes of TNF-α, IL-6, IL-8 and IL-10 in peripheral blood in both groups before and after treatment were observed and compared. The curative effect and incidence of adverse reactions were observed. Results: The total effective rate of clinical treatment in the experimental group was higher (P <0.05). After treatment, the levels of TNF-α, IL-6 and IL-8 in the two groups were significantly decreased Compared with the control group, the levels of TNF-α, IL-6 and IL-8 in the experimental group were lower than those in the control group (P <0.05) Compared with the control group, the incidence of adverse reactions in the experimental group was lower (P <0.05). Conclusion: Radix isatidis combined with azithromycin can significantly reduce the serum levels of TNF-α, IL-6, IL-8 and IL-10 in children with mycoplasma pneumonia and improve the therapeutic effect, which is of clinical significance.