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目的探讨早期胃癌发生转移的规律,为选择合适的治疗方案提供思路。方法收集2006年1月-2012年12月间安康市中心医院收治并确诊的早期胃癌患者118例,对8个可能与早期胃癌淋巴结转移发生有关的因素进行单因素和多因素logistic回归分析。结果有无溃疡、肿瘤大小、浸润深度及有无淋巴管浸润4个因素淋巴结转移率分别比较具有统计学意义(P<0.05);进一步多因素logistic回归分析显示,影响淋巴结转移的独立危险因素包括有溃疡、肿瘤大小≥3 cm、浸润深度至黏膜下层、有淋巴管浸润(OR值分别为2.872、2.351、3.461、1.784,均P<0.05)。结论早期胃癌发生淋巴结转移与多因素有关,建议术前严格筛查,排除各危险因素并选择合理的治疗方案。
Objective To explore the regularity of metastasis of early gastric cancer and provide ideas for choosing the appropriate treatment plan. Methods A total of 118 early gastric cancer patients admitted to Ankang Central Hospital from January 2006 to December 2012 were collected. One-factor and multivariate logistic regression analysis were used to analyze the eight factors that may be related to the occurrence of lymph node metastasis in early gastric cancer. Results There were statistically significant differences in lymph node metastasis rates of four factors including ulcer, tumor size, depth of invasion and lymphatic invasion (P <0.05). Further multivariate logistic regression analysis showed that independent risk factors affecting lymph node metastasis included There were ulcers, tumor size ≥ 3 cm, depth of invasion to the submucosa, with lymphatic invasion (OR = 2.872, 2.351, 3.46 1, 1.784, respectively, P <0.05). Conclusion The incidence of lymph node metastasis in early stage of gastric cancer is related to many factors. It is suggested that strict screening should be performed before operation, all the risk factors should be excluded and a reasonable treatment plan should be chosen.