论文部分内容阅读
目的对比分析利福喷丁、利福平治疗初治涂阳肺结核的临床疗效。方法回顾性分析2010年10月至2013年3月安阳市结核病防治所治疗的114例初治涂阳肺结核患者的临床记录资料,按治疗方法将其分为治疗组和对照组,各57例。治疗组采用LHZE方案治疗,对照组采用RHZE方案治疗,共治疗6个月。结果治疗组第2、4个月末及第6个月末的痰转阴率均高于对照组,差异均有统计学意义(P<0.05);治疗后,治疗组的病灶总有效率和空洞总改善率均高于对照组,差异有统计学意义(P<0.05);治疗组的治愈率高于对照组,失败率低于对照组,差异均有统计学意义(P<0.05);治疗组的胃肠道反应、皮疹、肝功能异常、白细胞减少的发生率均低于对照组,差异有统计学意义(P<0.05)。结论利福喷丁治疗初治涂阳肺结核的临床疗效显著,具有临床推广应用价值。
Objective To compare the clinical efficacy of rifapentine and rifampicin in the treatment of newly diagnosed smear positive pulmonary tuberculosis. Methods The clinical records of 114 newly diagnosed smear-positive pulmonary tuberculosis patients treated in Anyang TB Hospital from October 2010 to March 2013 were retrospectively analyzed. According to the treatment methods, they were divided into treatment group and control group, 57 cases each. The treatment group was treated with LHZE regimen, while the control group was treated with RHZE regimen for 6 months. Results The negative conversion rate of sputum in the 2nd, 4th, and the 6th month of the treatment group was significantly higher than that of the control group (P <0.05). After treatment, the total effective rate of the treatment group and the total empty cavity (P <0.05). The cure rate of the treatment group was higher than that of the control group, the failure rate was lower than that of the control group, the difference was statistically significant (P <0.05); the treatment group The incidence of gastrointestinal reactions, skin rashes, abnormal liver function and leukopenia were all lower than those in the control group (P <0.05). Conclusion The clinical efficacy of rifapentine in the treatment of newly diagnosed smear-positive pulmonary tuberculosis is significant and has clinical value of popularization and application.