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目的观察慢性阻塞性肺疾病(COPD)急性加重期患者和临床缓解期患者的血清瘦素、白介素8(IL-8)及白三烯B4(LTB4)含量变化。同时观察COPD患者血清瘦素与IL-8及LTB4含量的相关性。方法随机抽取COPD急性加重期患者、临床缓解期患者各38例,健康对照者36例,采用放射免疫法测定血清瘦素含量,采用双抗加心ELISA法测定IL-8和LTB4含量。结果 COPD急性加重期患者血清瘦素、IL-8和LTB4含量明显高于急性加重期患者和健康对照者,差异有统计学意义(P<0.05),COPD临床缓解期患者血清瘦素、IL-8和LTB4含量也明显高于健康对照者差异有统计学意义(P<0.05)。COPD急性加重期患者和临床缓解期患者血清IL-8和LTB4含量均与瘦素呈正相关。结论血清瘦素参与了COPD炎症过程,而与IL-8和LTB4呈正相关。
Objective To observe the changes of serum leptin, interleukin 8 (IL-8) and leukotriene B4 (LTB4) in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) and clinical remission. At the same time observe the correlation between serum leptin and IL-8 and LTB4 in patients with COPD. Methods A total of 38 patients with acute exacerbation of COPD and 38 patients with clinical remission were enrolled. Serum leptin levels were determined by radioimmunoassay. The levels of IL-8 and LTB4 were determined by double-antibody-plus-ELISA. Results The levels of serum leptin, IL-8 and LTB4 in patients with acute exacerbation of COPD were significantly higher than those in acute exacerbation and healthy controls (P <0.05). Serum leptin, IL- 8 and LTB4 were significantly higher than those in healthy controls (P <0.05). Serum levels of IL-8 and LTB4 in patients with COPD exacerbation and clinical remission were positively correlated with leptin. Conclusions Serum leptin is involved in the process of COPD inflammation, but positively correlated with IL-8 and LTB4.