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目的观察丹参酮ⅡA磺酸钠注射液对麻醉犬血流动力学的影响。方法采用麻醉犬在体心脏实验法,观察丹参酮ⅡA磺酸钠注射液对血流动力学各项参数的影响。结果丹参酮ⅡA磺酸钠注射液(1.25 mg/kg、2.5 mg/kg、5.0 mg/kg)组均能显著减慢麻醉犬心率(HR),增加冠状动脉流量(CBF);2.5 mg/kg、5.0 mg/kg剂量组能降低舒张压(DAP),减少总耗氧指数(TTI)、总外周血管阻力(TPVR),增加心搏指数(SI)、每搏输出量(SV),与对照组比较有显著性差异(P<0.05,P<0.01),但对心输出量(CO)和心脏指数(CI)无明显影响。结论丹参酮ⅡA磺酸钠注射液能改善麻醉犬血流动力学。
Objective To observe the effect of sodium tanshinone Ⅱ A sulfonate injection on hemodynamics in anesthetized dogs. Methods Anesthetized dogs in vivo heart test to observe the tanshinone Ⅱ A sodium injection on the hemodynamic parameters. Results Tanshinone ⅡA sodium sulfonate injection (1.25 mg / kg, 2.5 mg / kg, 5.0 mg / kg) significantly reduced heart rate (HR) and coronary flow (CBF) 5.0 mg / kg dose group could reduce diastolic blood pressure (DAP), reduce total oxygen consumption index (TTI), total peripheral vascular resistance (TPVR), increase heart rate index (SI) and stroke volume (SV) There was significant difference (P <0.05, P <0.01), but no significant effect on cardiac output (CO) and cardiac index (CI). Conclusion Tanshinone Ⅱ A Sodium Sulfate Injection can improve the hemodynamics of anesthetized dogs.