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目的对高龄孕妇的产前诊断结果、产前诊断率进行分析并探讨其影响因素。方法无菌条件下,取羊水细胞培养,常规收获,G显带,镜下核型分析。结果无产前诊断禁忌症的高龄孕妇有1530人,经详细的遗传咨询,充分告知产前诊断必要性,客观分析相关风险后选择羊穿人数535人,穿刺率35%;在这535例标本中,常染色体三体10例,检出率1.83%,其中21三体6例,18三体4例.结论新疆地区高龄孕妇穿刺率低,有多种客观因素影响;从中检出常染色体三体胎儿显著高于人群总检出率,高龄孕妇进行产前诊断对降低出生人口缺陷、提高人口素质具有特别重要的意义。
Objective To analyze the prenatal diagnosis and prenatal diagnosis of pregnant women and discuss the influencing factors. Methods Aseptic conditions, take amniotic fluid cell culture, routine harvest, G band, microscopic karyotype analysis. Results There were 1530 pregnant women without prenatal diagnosis of contraindications. After detailed genetic counseling, the necessity of prenatal diagnosis was fully informed. After the related risks were objectively analyzed, 535 sheep were selected and the puncture rate was 35%. In these 535 specimens , Autosomal trisomy 10 cases, the detection rate of 1.83%, of which 21 trisomy in 6 cases, 18 trisomy in 4. Conclusion Pregnant women in Xinjiang puncture rate is low, there are many objective factors; from the detection of autosomal trisomy Fetal was significantly higher than the total detection rate of the population, the elderly pregnant women to prenatal diagnosis of birth defects to reduce population, improve the quality of the population of particular importance.