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目的评价习惯性流产与染色体核型分布的关系。方法对110对习惯性流产夫妇进行外周血染色体核型分析。结果在受检的110对习惯性流产夫妇220例样品中,共检出异常染色体核型41例(女18例、男23例),总检出率为18.6%。在检出的41例染色体异常核型中常染色体结构异常有29例(70.7%),含平衡易位13例(39.02%),罗氏易位3例(7.32%)、臂间倒位3例(7.32%),随体增加5例(12.20%),次缢痕增加5例(12.20%);性染色体结构异常占12例29.3%。其中大Y染色体5例(12.20%),小Y染色体7例(17.07%)。结论习惯性流产与染色体异常核型密切相关,为降低发病率对夫妻双方进行产前筛查很有必要。
Objective To evaluate the relationship between habitual abortion and chromosomal karyotype distribution. Methods Peripheral blood karyotypes were analyzed in 110 pairs of habitual abortion couples. Results Totally 41 cases of abnormal chromosome karyotype (18 males and 23 males) were detected in 220 samples of 110 pairs of habitual abortion. The total detection rate was 18.6%. There were 29 cases (70.7%) with autosomal abnormalities in 41 cases of karyotype abnormalities, 13 cases (39.02%) with balanced translocation, 3 cases (7.32%) with Roche translocation and 3 cases 7.32%). There were 5 cases (12.20%) with stenosis and 5 cases (12.20%) with secondary stenosis. Sexual chromosomal abnormalities accounted for 29.3% in 12 cases. Among them, 5 were large Y chromosome (12.20%) and 7 were small Y chromosome (17.07%). Conclusion Habitual abortion is closely related to karyotype of chromosomal abnormalities. It is necessary to conduct prenatal screening for both husband and wife in order to reduce morbidity.