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目的:探讨新疆汉族2型糖尿病视网膜病变(DR)与胰岛素抵抗(IR)及β细胞功能的关系。方法:免散瞳眼底照相行眼底筛查我院内分泌科住院病人及体检正常人群258例,正常人(NC)83例、糖尿病无视网膜病变(NDR)60例、糖尿病视网膜病变(DR)115例,测定其空腹血糖(FBG)、空腹胰岛素(FINS),计算胰岛素抵抗指数(HOMA-IR指数)、β细胞功能指数(HOMA-β指数),并测定其临床一般资料,记录身高、体重等。结果:NDR组、DR组HOMA-IR指数、HOMA-β指数明显高于NC组,差异有统计学意义(p<0.05),但NDR组与DR组相比,HOMA-IR指数、HOMA-β指数差异无统计学意义(p>0.05)。2型糖尿病视网膜病变与FBG、FINS、HOMA-IR、HOMA-β呈正相关(p<0.01)。多元Logistic回归分析显示病程、吸烟史、TG、TC、尿微量白蛋白(UAE)、糖化血红蛋白(HbA1c)、血尿酸(SUA)、收缩压(SBP)HOMA-IR、HOMA-β为DR的危险因素。校正这些因素后DR仍与UAE、SUA、SBP、HOMA-IR、HOMA-β相关。结论:DR的发生与发展除了与病程、脂代谢紊乱、吸烟有关外,还与IR、β细胞功能、UAE及SUA等有关。
Objective: To investigate the relationship between type 2 diabetic retinopathy (DR) and insulin resistance (IR) and β-cell function in Xinjiang Han population. Methods: A total of 258 inpatients with in-patient endocrinology and normal physical examination in our hospital were enrolled in this study. There were 83 normal subjects (NC), 60 diabetic retinopathy (NDR), 115 diabetic retinopathy (DR) The fasting blood glucose (FBG), fasting insulin (FINS), insulin resistance index (HOMA-IR index) and β-cell function index (HOMA-β index) were measured and their general clinical data were recorded. Results: The HOMA-IR index and HOMA-β index in NDR group and DR group were significantly higher than those in NC group (p <0.05). However, compared with DR group, HOMA-IR index, HOMA-β There was no significant difference in index (p> 0.05). Type 2 diabetic retinopathy was positively correlated with FBG, FINS, HOMA-IR and HOMA-β (p <0.01). Multivariate logistic regression analysis showed that the duration of disease, smoking history, TG, TC, UAE, HbA1c, SUA, SBO HOMA-IR and HOMA-β were risk of DR factor. After adjusting for these factors DR still associated with UAE, SUA, SBP, HOMA-IR, HOMA-β. Conclusion: The occurrence and development of DR are related to IR, β-cell function, UAE and SUA in addition to the disease course, dyslipidemia and smoking.