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目的评估阿托伐他汀钙联合硝苯地平缓释片治疗老年轻中度高血压合并快速性心律失常的临床疗效及其对肝肾功能的影响。方法 138例患者分为2组,对照组给予硝苯地平缓释片治疗,治疗组在此基础上加用阿托伐他汀钙治疗。治疗18个月后,复查Holter心电图,观察心律失常情况,复查肝肾功能相关指标,血压控制情况。结果与治疗前相比,2组收缩压、舒张压均显著下降,但治疗组低于对照组,组间和组内差异有统计学意义(P<0.05);2组房性早搏、室性早搏及房颤发生率均较治疗前降低,但治疗组低于对照组,组间和组内差异有统计学意义(P<0.05);治疗组2例转氨酶升高。结论两种药物治疗老年高血压疗效更优,且无明显肝肾损害。
Objective To evaluate the clinical efficacy of atorvastatin combined with nifedipine sustained release tablets in the treatment of elderly mild to moderate hypertension complicated with tachyarrhythmia and its effect on liver and kidney function. Methods 138 patients were divided into two groups, the control group was treated with nifedipine sustained-release tablets, the treatment group on this basis plus atorvastatin calcium treatment. After 18 months of treatment, review the Holter electrocardiogram, observe the arrhythmia, review the indexes of liver and kidney function, and control the blood pressure. Results Compared with those before treatment, the systolic blood pressure and diastolic blood pressure in the two groups were significantly decreased, but the treatment group was lower than the control group, the difference was statistically significant (P <0.05) between the two groups (P <0.05) The incidence of premature beats and atrial fibrillation were lower than those before treatment, but the treatment group was lower than the control group, with significant difference between groups and groups (P <0.05). Two cases of transaminases increased in the treatment group. Conclusion The two drugs are superior to the treatment of senile hypertension, and no significant liver and kidney damage.