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作者报告1例成人T细胞白血病患者用α干扰素(IFN-α)治疗获得明显好转的结果。患者男性,61岁。1982年3月出现皮肤红斑。1983年4月因肝脾肿大伴腹水而入院。根据血液学检查结果诊断为成人T细胞白血病。入院后,联合化疗6个疗程,虽能降低白细胞总数,但不能去除白血病细胞。遂用重组人IFN-α治疗,剂量为每日3×10~6IU,连续应用40天。治疗后,白血病细胞的百分率明显降低。停药后白血病细胞数继续下降。
The authors report a clear improvement in treatment of patients with adult T-cell leukemia with interferon-alpha (IFN-α). Male patient, 61 years old. March 1982 skin erythema. April 1983 due to hepatosplenomegaly with ascites and admission. According to the results of hematological diagnosis of adult T-cell leukemia. After admission, combined chemotherapy 6 courses, although can reduce the total number of leukocytes, but can not remove leukemia cells. Then with recombinant human IFN-α treatment, the dose of 3 × 10 ~ 6IU daily for 40 days. After treatment, the percentage of leukemia cells was significantly reduced. After stopping the number of leukemia cells continue to decline.