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竞争性蛋白结合分析法是一种放射性体外测量的新技术。利用自由血清甲状腺素(T_4)有在~(125)碘标记的甲状腺结合球蛋白(TBG)结合处置换出~(125)碘-T_4的能力,来进行 T_4的定量测定。这是一种特异性较强、灵敏度较高的判断甲状腺机能:状态的检查方法之一。我们自1976年11月起采用了改良 Murphy 氏法测定健康成人、甲状腺疾病患者及晚孕妇女的血清总 T_4含量。现小结于下。
Competitive protein binding assay is a novel radioactive in vitro measurement technique. Quantitative determination of T_4 was performed using free thyroxine (T_4) in the presence of ~ (125) iodine-labeled thyroid binding globulin (TBG) at its binding site for the exchange of ~ (125) iodine-T_4. This is a more specific, high sensitivity to determine thyroid function: one of the state inspection methods. Since November 1976, we have used modified Murphy’s method to determine the serum total T 4 content in healthy adults, thyroid disease patients and pregnant women. Now summarized in the next.