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目的 :观察术前未化疗、术前化疗、术前化疗联合干扰素 +CD3AK细胞治疗结肠癌患者术后的近期机体免疫功能变化 ,找出满意的治疗方案。方法 :对 5 6例确诊为结肠癌又未发现有远处转移的患者随机分A、B、C 3组。A组不行术前化疗 ,B组行术前化疗 ,C组行术前化疗并加用干扰素、CD3AK细胞 ,比较化疗前、化疗后 1周、术后 1、2、3周的机体免疫状态。结果 :术前化疗可严重抑制机体免疫功能 ,手术亦引起机体免疫功能下降。术前化疗加用干扰素、CD3AK细胞治疗可使机体免疫功能于化疗后明显提高 ,且于术后维持在高水平状态。结论 :新辅助化疗加用干扰素及CD3AK细胞治疗是一种安全有效的抗肿瘤方法
OBJECTIVE: To observe the changes of immune function in patients with colon cancer treated with preoperative chemotherapy, preoperative chemotherapy, preoperative chemotherapy combined with interferon + CD3AK cells and to find out the satisfactory treatment plan. Methods: A total of 56 patients diagnosed with colon cancer and no distant metastasis were randomly divided into groups A, B and C. Group A received preoperative chemotherapy, Group B received preoperative chemotherapy, Group C received preoperative chemotherapy plus interferon and CD3AK cells, and compared the immune status before chemotherapy, 1 week after chemotherapy, 1, 2, and 3 weeks after surgery . Results: Preoperative chemotherapy can significantly inhibit the immune function, surgery also caused the body’s immune function decline. Preoperative chemotherapy plus interferon, CD3AK cell therapy can make the body’s immune function was significantly improved after chemotherapy, and maintained at a high level after surgery. Conclusion: neoadjuvant chemotherapy plus interferon and CD3AK cell therapy is a safe and effective anti-tumor method