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固相合成法,是十多年前R.B.Merrifield在四肽和核糖核酸酶A,以及R.L.Letsinger在寡核甙酸的多步合成中开始应用的方法。一、用苯乙烯型树脂为载体的固相合成法 I.在有机合成反应中的应用自Merrifield等多肽合成的工作以来,已有很多有机合成试剂、有机过渡金属催化剂和光敏剂被结合于固体聚合物而用于有机合成。与可溶性试剂相比较,这些连结于固体聚合物的试剂,具有操作方便,回收再用或再生较为容易,以及生成物收率高等共同的长处。
Solid-phase synthesis is a method used by R.B. Merrifield more than a decade ago for tetrapeptides and ribonuclease A, and R.L. Letsinger for multi-step synthesis of oligonucleotides. A solid-phase synthesis method using styrenic resin as a carrier I. Application in organic synthesis reactions Since the work of synthesis of peptides such as Merrifield, there have been many organic synthesis reagents, and organic transition metal catalysts and photosensitizers have been incorporated into the solid Polymers for organic synthesis. Compared with soluble reagents, these reagents linked to the solid polymer have the advantages of easy operation, easier recovery and recycling, better regeneration, and higher yields of the products.