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法莫替丁是一治疗胃溃疡的新H_2受体拮抗剂。由于该药剂量较小,须以灵敏、准确的方法进行测定。用本法测定其片剂中含量,可不受其分解产物及常见赋形剂干扰,并可用于片剂的溶出度测定。色谱条件 Lichrosorb 7μRP_(18)柱(250×46 mm),流动相为0.01 mol磷酸缓冲液:乙腈:甲醇(84∶11∶5),混合后用磷酸调至pH6.5流速每分钟1.8 ml,检测波长280 nm,进样量50μl。内标为茶碱,峰高比定量。标准曲线取法莫替丁适量(?)以流动相配成0.1mg/ml溶液,分别取适量,加内标
Famotidine is a new H 2 receptor antagonist for the treatment of gastric ulcers. Due to the small dose of the drug, it should be determined in a sensitive and accurate way. Determination of the content of the tablet by this method can not be disturbed by its decomposition products and common excipients, and can be used for tablet dissolution determination. Chromatographic conditions Lichrosorb 7μ RP_ (18) column (250 × 46 mm), mobile phase 0.01 mol phosphate buffer: acetonitrile: methanol (84:11:5), adjusted to pH6.5 with phosphoric acid after mixing 1.8 ml per minute, Detection wavelength 280 nm, injection volume 50μl. Internal standard for theophylline, peak-to-volume ratio. Standard curve to take the amount of famotidine (?) Mobile phase matched 0.1mg / ml solution, respectively, take the right amount, plus internal standard