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【目的】观察奥曲肽对胰头癌胆道支架置入术后胰腺炎和高淀粉酶血症的预防作用。【方法】收集2011年8月至2014年7月行胆道支架置入术的胰头癌患者82例，术前30 min只常规给药者为对照组（ n＝42），加用奥曲肽者为观察组（ n＝40）。记录受试者术前1 d、术后3 h、24 h血清淀粉酶水平，淀粉酶恢复正常所需时间，统计术后胰腺炎和高淀粉酶血症的发生率。【结果】术后3 h、24 h血清淀粉酶水平观察组均明显低于对照组（123．5±67．6vs．235．2±128．6；166．2±130．6vs．345．1±209．8），术后胰腺炎和高淀粉酶血症的发生率观察组均较对照组低，血清淀粉酶恢复正常所需天数观察组（2．75±0．71）低于对照组（4．83±1．27），所有数据均有统计学意义（ P＜0．05）。【结论】奥曲肽能预防胰头癌胆道支架置入术后胰腺炎和高淀粉酶血症。“,”Objective] To explore the prevention of octreotide on post‐endoscopic retrograde cholangiopancre‐atography (ERCP) pancreatitis and hyperamylasemia in patients with carcinoma of head of pancreas after biliary stent‐ing .[Methods] A total of 82 patients with carcinoma of head of pancreas after biliary stenting were collected from August 2011 to July 2007 .At 30 min pre‐ERCP ,control group received routine drugs ( n=42) while octreotide was added for observation group ( n=40) .The serum levels of amylase at Day 1 pre‐ERCP and 3 h ,24 h post‐ERCP were measured .Amylase recovery time was recorded .And the inter‐group incidences of post‐ERCP pancreatitis were compared .[Results]The serum levels of amylase in observation group at 3h and 24 h post‐ERCP were all significant‐ly lower than those in control group (123 .5 ± 67 .6 vs 235 .2 ± 128 .6;166 .2 ± 130 .6 vs 345 .1 ± 209 .8) .And the in‐cidences of post‐ERCP pancreatitis and hyperamylasemia were all significantly lower in observation group than those in control group .The days required for normalization of serum amylase in observation group (2 .75 ± 0 .71) were lower than those of control group (4 .83 ± 1 .27) .All differences were statistically significant ( P<0 .05) .[Conclusion]Oc‐treotide may prevent post‐ERCP pancreatitis and hyperamylasemia in patients with carcinoma of head of pancreas after biliary stenting .