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[目的]收集17例中枢神经系统原发性淋巴瘤 ,对其临床病理特点及免疫组化染色特征进行探讨。[方法]标本采用常规石蜡切片、HE染色及SP法免疫组化染色 ,光镜观察。[结果]17例患者中男性12例 ,女性5例 ;中位年龄50岁。17例中肿瘤位于顶叶5例 ,额叶4例 ,颞叶和基底节区各3例 ,小脑2例。16例肿瘤细胞呈弥漫围绕血管分布 ,仅1例在肿瘤内可见部分滤泡形成。17例肿瘤细胞均为LCA阳性表达 ,其中16例L26阳性 ,1例UCLH1阳性。[结论]PCNSL好发于50岁左右男性患者 ,以顶、额叶多见。镜下见肿瘤细胞多呈弥漫围绕血管分布。免疫组化染色证明肿瘤多为B细胞性淋巴瘤 ,T细胞性淋巴瘤较罕见
[Objective] To collect 17 cases of central nervous system primary lymphoma, and to investigate its clinicopathological features and immunohistochemical staining characteristics. [Methods] The specimens were stained with paraffin, HE staining and SP immunohistochemistry, and observed with light microscope. [Results] Among the 17 patients, there were 12 males and 5 females. The median age was 50 years. In 17 cases, the tumors were located in the parietal lobe in 5 cases, frontal lobe in 4 cases, temporal lobe and basal ganglia in 3 cases, and cerebellum in 2 cases. 16 cases of tumor cells were diffuse around the blood vessels, only 1 case of visible in the tumor follicular formation. All the 17 tumor cells were positive for LCA, of which 16 were positive for L26 and 1 were positive for UCLH1. [Conclusion] PCNSL occurs predominantly in male patients aged about 50 years, with top and frontal lobes more common. Microscopic tumor cells were mostly diffuse around the blood vessels. Immunohistochemical staining showed that most of the tumors were B-cell lymphoma and T-cell lymphoma was rare