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可逆性不佳是棉酚作为男用抗生育药物研究的另一重要问题。为解决棉酚的毒副反应,对低剂量棉酚抗生育进行临床研究,初步证明将以往棉酚给药量减少40％,可保持有效的抗生育作用,而避免毒副反应。观察本给药方案是否有利于改善停药后生精的恢复,对6例服用低剂量棉酚的受试者作了停药后的定期随访.6例均为年龄20～40岁的健康男性已有正常生育.口服醋酸消旋棉酚15mg/d连续60 d,以
Reversible poor gossypol as male anti-fertility drug research is another important issue. To solve the side effects of gossypol, a clinical study on the anti-fertility of low-dose gossypol was conducted. It was initially proved that the dosage of gossypol was reduced by 40% in the past and the effective anti-fertility effect could be maintained without any toxic side effects. To observe whether this drug regimen is helpful to improve the recovery of spermatozoa after stopping drug, 6 patients taking low dosage of gossypol were given regular follow-up after discontinuation.All the 6 healthy males aged from 20 to 40 years Have normal childbirth.Oral acetic acid racemic gossypol 15mg / d for 60 days, with