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用 HPLC 法测定了地尔硫片剂在健康志愿者体内的血药浓度,其从血清的绝对回收率约为72%。其最低检测限为5ng/ml。比较了国产和日本生产的两种片剂(30mg/片)在人体的相对生物利用度,结果的统计学处理表明,两者主要参数无显著差异。
The plasma concentration of diltiazem tablet in healthy volunteers was determined by HPLC. The absolute recovery from serum was about 72%. The minimum detection limit of 5ng / ml. The relative bioavailability of two tablets (30 mg / tablet) produced in China and Japan was compared with that of the human body. The statistical analysis of the results showed that there was no significant difference between the two main parameters.