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p21WAF1/CIP1是由细胞增殖抑制基因WAF1(wide type p53 activated factor 1)编码的21kDa的蛋白,属于Cip/Kip家族。作为1种细胞周期蛋白激酶(Cds)抑制剂,p21WAF1/CIP1与肿瘤的分化、浸润深度、增生和转移有关,具有判断肿瘤分化程度和预后的价值[1-4],与肿瘤化疗耐药机制的产生密切相关。1 p21WAF1/CIP1介导化疗耐药的作用机制1.1 p21WAF1/CIP1介导细胞周期G1停滞机制p21WAF1/CIP1是细胞周期依赖性激酶抑制蛋白(CDKs)家族中重要的调节因子,其调节细胞周期的作用途径分为p53依赖型途径和p53非依赖型途径[1-2]。
p21 WAF1 / CIP1 is a 21 kDa protein encoded by the wide type p53 activated factor 1 gene and belongs to the Cip / Kip family. As a cyclin kinase (Cds) inhibitor, p21WAF1 / CIP1 is associated with tumor differentiation, depth of invasion, proliferation and metastasis, and has the value of determining tumor differentiation and prognosis [1-4] The production is closely related. Mechanisms of p21WAF1 / CIP1-mediated Chemoresistance1.1 Mechanisms of p21WAF1 / CIP1-Mediated Cell Cycle G1 Histopathology p21WAF1 / CIP1 is an important regulator of the cell cycle-dependent kinase inhibitor protein (CDKs) family and regulates the cell cycle Pathways are divided into p53-dependent and p53-independent pathways [1-2].