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生物抗菌肽 (antibacterialpeptides)广泛存在于昆虫、植物、动物及人体内 ,有非特异性抗细菌、真菌、病毒和肿瘤细胞的作用 ,又称为肽抗生素 (peptideantibiotics)。抗菌肽是通过其两亲性正电荷与细菌细胞膜磷脂分子负电荷的静电吸引而结合在细菌膜上 ,疏水端插入细胞膜中 ,最终通过膜内分子间的位移而聚集在一起形成离子通道 ,使细菌失去膜电势 ,不能维持正常渗透压而死亡。抗菌肽杀菌力强 ,抗菌谱广 ,不良反应少 ,将会给临床医学、临床药学、食品防腐、动植物转基因等领域带来广阔的开发应用前景
Antibiotic peptides are widely found in insects, plants, animals and humans and have nonspecific anti-bacterial, fungal, viral and tumor cell functions, also known as peptide antibbiotics. Antibacterial peptides are bound to the bacterial membrane through the electrostatic attraction of the amphipathic positive charges and the negative charges of the bacterial cell membrane phospholipid molecules. The hydrophobic end is inserted into the cell membrane, and eventually the ion channels are formed through the intramolecular displacement of the membrane to form ion channels Bacteria lose membrane potential, can not maintain the normal osmotic pressure and death. Antibacterial peptides bactericidal power, broad antibacterial spectrum, adverse reactions, will give clinical medicine, clinical pharmacy, food preservatives, animal and plant gene transgenics and other fields to bring broad prospects for the development and application