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目的探讨老年高血压患者高敏C反应蛋白(hsCRP)与心、肾及血管靶器官损害的关系。方法选择心内科住院,年龄≥60岁的老年原发性高血压患者80例,检测hsCRP、晨尿白蛋白与尿肌酐的比值(ACR)、左心室重量指数(LVMI)及颈动脉内膜中层厚度(IMT)。结果 LVH组hsCRP水平和收缩压明显高于非LVH组,差异有统计学意义(P<0.05)。IMT增厚组hsCRP水平和收缩压明显高于正常IMT组,差异有统计学意义(P<0.05)。MAU组hsCRP水平明显高于无MAU组,差异有统计学意义(P<0.05)。相关分析显示,hsCRP与LVMI、IMT、ACR呈正相关(r值分别为0.504、0.431、0.384,均P<0.01)。hsCRP是LVMI、ACR及IMT的独立影响因素。结论 hsCRP与老年高血压患者靶器官损害程度呈正相关。
Objective To investigate the relationship between high sensitivity C-reactive protein (hsCRP) and heart, kidney and vascular target organ damage in elderly patients with hypertension. Methods Eighty elderly essential hypertension patients aged> 60 years were enrolled in this study. The serum hsCRP, morning urine albumin to urinary creatinine (ACR), left ventricular mass index (LVMI) and carotid intima-media thickness Thickness (IMT). Results The hsCRP level and systolic pressure in LVH group were significantly higher than those in non-LVH group (P <0.05). The hsCRP level and systolic pressure in IMT thickening group were significantly higher than those in normal IMT group (P <0.05). The hsCRP level in MAU group was significantly higher than that in no MAU group (P <0.05). Correlation analysis showed that there was a positive correlation between hsCRP and LVMI, IMT and ACR (r = 0.504,0.431,0.384, all P <0.01). hsCRP is an independent influencing factor for LVMI, ACR and IMT. Conclusion There is a positive correlation between hsCRP and target organ damage in elderly patients with hypertension.