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目的:探讨肿瘤坏死因子α(tumor necrosis factor-alpha,TNF-α)基因-308G>A,-238G>A多态性与原发性高血压动脉粥样硬化的关系。方法:对河南汉族人群212例原发性高血压患者进行颈动脉超声检测,根据检测结果将患者分为颈动脉粥样硬化组和颈动脉正常组,采用聚合酶链反应-限制性片段长度多态性方法检测TNF-α基因-308G>A,-238G>A多态性。结果:颈动脉粥样硬化组与颈动脉正常组TNF--α308G>A及TNF--α238G>A基因型及等位基因的分布比较差异均有统计学意义(P<0.05)。结论:TNF--α308G>A,-238G>A基因多态性与河南汉族原发性高血压动脉粥样硬化的发生有关。
Objective: To investigate the relationship between the polymorphisms of -308G> A and -238G> A in patients with essential hypertension and atherosclerosis of essential hypertension. Methods: A total of 212 patients with essential hypertension in Henan Han population were examined by carotid ultrasonography. Patients were divided into carotid atherosclerosis group and carotid artery normal group according to the test results. Polymerase chain reaction-restriction fragment length The polymorphisms of -308G> A and -238G> A of TNF-α gene were detected by morphological methods. Results: There were significant differences in the distribution of TNF - α308G> A and TNF - α238G> A genotypes and alleles between carotid atherosclerosis and normal carotid arteries (P <0.05). Conclusion: The polymorphisms of TNF - α308G> A and -238G> A are associated with the occurrence of atherosclerosis in the Han nationality in Henan province.