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对服用雷公藤治疗结缔组织疾病引起闭经的９例育龄期妇女进行了性激素水平的对比测定，同时Ｂ超探查子宫情况。结果，用药组９例ＦＳＨ（卵泡刺激素），ＬＨ（黄体生成素）分别为８１１６±４４２５ｍＵ／Ｌ，８７８４±６７１０ＩＵ／Ｌ，明显高于未用药组８６７±３８１ｍＵ／Ｌ和１０９６±１５９０ＩＵ／Ｌ（Ｐ＜０００１和Ｐ＜００５）。Ｅ２（雌二醇），ＰＲＬ（催乳素）分别为２２３０±２９６２ｐｍｏｌ／Ｌ，１２６３±４７３μｇ／Ｌ，明显低于未用药组５８０８８±４７０８ｐｍｏｌ／Ｌ，１９５７±１１９４μｇ／Ｌ（Ｐ＜００５）。用药组６例伴有子宫萎缩，未用药组正常，其中用药组７例符合高促性腺性闭经，提示卵巢功能减退或衰竭。因此，育龄期妇女使用该药时应慎重。
9 cases of women of childbearing age who received tripterygium for the treatment of connective tissue diseases were tested for sex hormone levels and ultrasound examination of the uterus was performed. Results, FSH (follicle stimulating hormone) and LH (LH) in the medication group were 8116 ± 4425mU / L, 8784 ± 6710IU / L, which were significantly higher than those of the untreated group ± 381mU / L and 1096 ± 1590IU / L (P <0001 and P <005). E2 estradiol and prolactin were 2230 ± 2962 pmol / L and 1263 ± 473 μg / L, respectively, which were significantly lower than 58088 ± 47088 pmol / L, 1957 ± 1194μg / L (P <005). The treatment group with 6 cases of uterine atrophy, no treatment group normal, including the treatment group of 7 cases of gonadal hyperparathyroidism, suggesting ovarian dysfunction or failure. Therefore, women of childbearing age should be careful when using this medicine.