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目的：探讨Ｔ细胞亚群与类风湿性关节炎（Ｒｈｅｕｍａｔｏｉｄａｒｔｈｒｉｔｉｓ，ＲＡ）的关系及类风湿性关节炎的发生发展变化与细胞免疫功能的关系。方法：采用免疫荧光染色法和流式细胞仪检测５６例ＲＡ患者及４５例正常人外周血ＣＤ４＋、ＣＤ８＋细胞数。结果：正常人血浆ＣＤ４＋细胞数（４３．５２±２．１６）％，ＣＤ８＋细胞数（２２．３８±１．９８）％，ＲＡ患者ＣＤ４＋（４５．１８±３．２７）％，ＣＤ８＋（１５．０５±３．１５）％。ＣＤ４＋／ＣＤ８＋比值较正常人高（Ｐ＜０．０５），且ＲＡ患者中活动期与非活动期相比亦有显著性差异（Ｐ＜０．０５）。结论：本研究提示细胞免疫状态参与了ＲＡ的发病过程；进一步了解其作用机理，对ＲＡ的防治具有重要意义。
Objective: To investigate the relationship between T cell subsets and rheumatoid arthritis (RA) and the relationship between the occurrence and development of rheumatoid arthritis and cellular immune function. Methods: The numbers of CD4 + and CD8 + cells in 56 RA patients and 45 normal persons were detected by immunofluorescence staining and flow cytometry. Results: The percentage of CD4 + cells (43.52 ± 2.16)%, CD8 + cells (22.38 ± 1.98)%, CD4 + (45.18 ± 3.27)%, CD8 + .05 ± 3.15)%. The ratio of CD4 + / CD8 + was higher than that of normal people (P <0.05). There was also a significant difference between active and inactive patients in RA patients (P <0.05). Conclusion: This study suggests that cellular immune status is involved in the pathogenesis of RA. To further understand its mechanism of action is of great significance for the prevention and treatment of RA.