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作者对 97例阿片依赖所致失眠应用唑吡坦与苯二氮类治疗 ,进行临床双盲对照研究 ,通过十天的临床治疗观察 ,对一般情况、睡眠进程、睡眠结构、REM睡眠指标、注意力测查、不良反应和停药后不良症状等七个方面的对照研究 ,结果显示 ,唑吡坦对苯二氮类治疗阿片依赖所致失眠在入睡时间、清醒次数、睡眠总时间、睡眠质量、注意力测查 (主观评估 )、不良反应和停药后不良症状等方面的研究均有显著性差异 ( P<0 .0 5) ,唑吡坦治疗阿片依赖所致失眠安全、可靠、副作用小 ,停药后未发现戒断症状 ,反弹性失眠和耐药性等不良症状 ,临床疗效良好。
The author of 97 cases of opioid insomnia with zolpidem and benzodiazepine treatment, clinical double-blind control study, through 10 days of clinical observation, general conditions, sleep progress, sleep structure, REM sleep indicators, Attention check, adverse reactions and adverse symptoms after stopping the control study of seven aspects, the results show that zolpidem benzodiazepine treatment of insomnia caused by opioid dependence in falling asleep time, awake times, total sleep time, Sleep quality, attention test (subjective assessment), adverse reactions and withdrawal symptoms after the study showed significant differences (P <0. 05), zolpidem treatment of opiate dependence insomnia safe and reliable , Small side effects, no withdrawal symptoms after withdrawal, rebound insomnia and drug resistance and other adverse symptoms, clinical efficacy is good.