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目的了解江苏省徐州市健康体检者肾功能下降状况及其危险因素,为采取干预措施提供参考依据。方法收集徐州市中心医院2006—2009年77355名健康体检者体检资料进行回顾性分析。结果 77355名健康体检者肾功能下降患病率为1.18%,标化患病率为1.30%;其中男性和女性的患病率分别为1.19%和1.18%,差异无统计学意义(P>0.05);20～、30～、40～、50～、60～、70～和≥80岁年龄组患病率分别为0.10%、0.20%、0.52%、1.20%、3.30%、7.62%和11.58%,不同年龄组差异有统计学意义(χ2=2734.34,P=0.000);男性和女性肾功能下降率均随年龄的增长呈上升趋势(P=0.000),平均每10年分别增长1.85%和2.18%;多因素lo-gistic回归分析结果表明,血浆粘度偏高、蛋白尿、白细胞尿、红细胞尿、低密度脂蛋白偏高、空腹血糖偏高、收缩压偏高、血尿酸偏高是肾功能下降的危险因素。结论徐州市健康体检者肾功能下降患病率较低,有蛋白尿、白细胞尿、红细胞尿以及血浆粘度、低密度脂蛋白、空腹血糖、收缩压、血尿酸偏高是肾功能下降的危险因素。
Objective To understand the status of renal function decline and its risk factors in Xuzhou City, Jiangsu Province, and to provide reference for the intervention measures. Methods A retrospective analysis was carried out on the physical examination data of 77,355 healthy people from Xuzhou Central Hospital from 2006 to 2009. Results The prevalence of decreased renal function was 1.18% in 77 355 healthy subjects and the normalized prevalence was 1.30%. The prevalence rates of male and female were 1.19% and 1.18% respectively, with no significant difference (P> 0.05 ). The prevalences in the 20, 30, 40, 50, 60, 70 and 80 years old group were 0.10%, 0.20%, 0.52%, 1.20%, 3.30%, 7.62% and 11.58% (Χ2 = 2734.34, P = 0.000). The decline rate of renal function in both men and women increased with age (P = 0.000), with an average increase of 1.85% and 2.18 %; Multivariate logistic regression analysis showed that the high plasma viscosity, proteinuria, leukocyturia, erythrocyte urine, high-density lipoprotein, high fasting blood glucose, high systolic blood pressure, high serum uric acid is renal function Declining risk factors. Conclusions The prevalence of renal dysfunction in Xuzhou healthy people is low, and proteinuria, leucocytosis, erythrocyte urine and plasma viscosity, low density lipoprotein, fasting blood glucose, systolic blood pressure and high blood uric acid are the risk factors of decreased renal function .