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由于白血病化疗的进展,早幼粒细胞白血病(APL)的预后已得到改善。但化疗致大量幼雅细胞的杀灭,引起骨髓抑制,病死率仍很高。近年来,使用诱导分化治疗APL,使不成熟的早幼粒细胞在诱导下分化为成熟中性粒细胞,以达到临床及髓象的缓解,为本病的治疗开辟了新的前景。近年来作者,用全反式维甲酸(ATRA)治疗APL和骨髓异常增生综合征(MDS)共12例,取得较满意效果,总缓解率83.3％,现报道如下:
Prognosis of promyelocytic leukemia (APL) has been improved due to advances in leukemia chemotherapy. However, a large number of chemotherapy caused by the killing of young cells, causing bone marrow suppression, mortality is still high. In recent years, the use of induced differentiation for the treatment of APL, so that immature promyelocytic differentiation into mature neutrophils in order to achieve clinical and medullary image relief for the treatment of this disease has opened up new prospects. In recent years, the authors, with all-trans retinoic acid (ATRA) treatment of APL and myelodysplastic syndrome (MDS) in 12 cases, achieved more satisfactory results, the overall response rate was 83.3%, are reported as follows: