论文部分内容阅读
庆大霉素(GTM)药动学特性与制订其合理给药方案有密切关系。过去报告常以一房室模型特征作为给药依据,长期认为只要峰浓度保证在治疗窗内,是安全的。但在连续10天给药对肾功能是否有影响尚不清楚。本文通过对10例临床病人着重研究了GTM不同采血时间的房室模型和多剂量给药时的药动学特征及对肾功能的影响。实验表明GTM的房室模型与采血时间密切相关,>8～24小时表现为二房室模型,<8小时为一房室模型。连续多剂量给药会使GTM体内药物的排泄减慢,有部分病人显示肾小管损害。
The gentamicin (GTM) pharmacokinetics is closely related to the formulation of its rational drug delivery regimen. In the past, the report often used the characteristics of one-compartment model as the basis for drug administration. It has long been believed that as long as the peak concentration is guaranteed within the therapeutic window, it is safe. However, it is unclear whether administration on consecutive 10 days has an effect on renal function. In this paper, 10 cases of clinical patients focused on different GTM sampling time chamber model and multi-dose pharmacokinetics and renal function. Experiments show that GTM atrioventricular model and blood collection time is closely related to the> 8 to 24 hours showed a two-compartment model, <8 hours for a one-compartment model. Continuous multi-dose administration will slow the excretion of GTM in vivo and some patients may show renal tubular damage.