高效液相色谱法测定盐酸头孢他美酯的含量

• 作 者: 党玉芳 芦松萍 吴永淳 刘春凤 秦雅英
• 机 构: 黑龙江省铁力农场医院,黑龙江省药品检验所,哈尔滨制药三厂
• 出 处: 中医药信息
• 发表日期: 1999年03期
• 关键词: 盐酸头孢他美酯 高效液相色谱法 流动相 精密量取 外标法 哈尔滨制药三厂 对照品 样品测定 回收率试验 已知量

盐酸头孢他美酯是国内最新研制的四类新药。其含量测定方法国内尚无报导，本文参照日本同类产品的报导，采用ＨＰＬＣ法，改用甲醇－水为流动相，测定其盐酸头孢他美酯的含量。该方法准确，ＲＳＤ为０．１％，结果在０．５～４μｇ间呈良好的线性，ｒ＝０．９９８８。仪器...

Ceftazidime hydrochloride is the latest four kinds of new drugs developed in China. There is no report about its content determination method in our country. In this paper, with reference to the reports of similar products in Japan, the content of ceftazidime hydrochloride was determined by HPLC with methanol-water as the mobile phase. The method is accurate, with a RSD of 0.1% and a good linearity of 0.5-4 μg with r = 0.9988. instrument...