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目的探讨Ki-67鳞细胞等在胃食管反流病(GERD)中的表达及意义。方法将1982例本地居民胃食管反流病流行病学调查结果筛选分组的病例经内镜检查活检，并对其石蜡标本采用免疫组化SP染色法检测,检测Ki-67鳞细胞等在BE、慢性食管炎及正常食管黏膜中的表达，分析其免疫组化特点。结果150例内镜活检组织进行免疫组化，结果比较Barrett食管(BE)、EGFR腺细胞、CK-H腺细胞、CK-L鳞细胞和CK-L腺细胞五个指标在两组间差异均无统计学意义。 Ki-67的鳞细胞、腺细胞等差异有显著性(P<0.005)。结论 Ki-67鳞细胞（%）与发生GERD之间有较大关联；Ki-67鳞细胞（%）为发生 GERD的危险性指标，Ki-67鳞细胞可能参与胃食管反流病的发生发展过程。“,”Objective To investigate the expression and significance of Ki-67 squamous cel in gastroesophageal reflux disease. Methods Endoscopy and biopsy were performed in 150 soldier cases who were screened and grouped by gastroesophageal reflux disease epidemiology investigation. The expression of Ki-67 squamous cel s of these paraf in specimens in Barret esophagus, chronic esophagitis and normal esophageal mucosa were detected by immunohistochemical SP staining method. Through the data,we analyzed its immunohistochemical characteristics. Results The dif erences of five indicators including Barret esophagus (BE), EGFR gland cel , CK - H gland cel ,CK-L squamous cel and CK-L gland cel between the two groups had no statistical significance. There was significant dif erence between Ki - 67 squamous cel and gland cel (P<0.005). Conclusions Ki-67 squamous cel had larger correlation with GERD, and was the risk indicator of GERD.Ki - 67 squamous cel s may participate in the development process of gastroesophageal reflux disease.