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近年来,上尿路结石的发病率显著增加。据Scott随意调查了一组3,398人的人群中上尿路结石病人占3.5%,其中有12%的男性结石病人会出现肾及输尿管绞痛,大约半数的结石病人绞痛于5年内会再次复发。临床上对绞痛病人的治疗除阿片类制剂外几无对策,而阿片类镇痛剂的成瘾性又限制了其应用。因此,进一步探讨肾及输尿管绞痛的病理生理及筛选理想的治疗药物为临床亟需解决的课题。
In recent years, the incidence of upper urinary tract stones increased significantly. Scott randomly surveyed a group of 3,398 people in 3.5% of patients with upper urinary tract stones, of whom 12% had calculus of kidney and ureter and about half of those with calculus developed recurrence within 5 years . Clinically, patients with angina treatment in addition to opioids outside the few countermeasures, and opioid analgesics addiction and limit its application. Therefore, to further explore the pathophysiology of renal and ureteral angina and screening the ideal therapeutic drug for clinical problems to be solved.