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了解柳珊瑚酸（ｓｕｂｅｒｏｇｏｒｇｉｎ，Ｓｕｂ）抗利尿作用的机制．方法：清醒大鼠给予水负荷后ｉｇ Ｓｕｂ３．１６ ｍｇ·ｋｇ－１，收集尿液，用原子发射光谱仪测定尿离子的总排出量；放射免疫法测尿ＰＧＥ以及血浆ＰＧＥ， ＡＤＨ和醛固酮水平。结果：给药后 ２４ ｈ内，Ｓｕｂ减少正常大鼠的累积尿量以及钠和钾的总排出量（最大值分别为９１％， ７６％和８６％），此作用随时间逐渐减弱，并可因大鼠去垂体而几乎完全消失，但不受去肾上腺影响．给药后２ｈ，Ｓｕｂ使尿ＲＧＥ以及血浆ＰＧＥ和ＡＤＨ浓度分别提高２５％， ２１２％和５３８％，但不影响醛固酮水平．结论：Ｓｕｂ的水潴留作用缘于它促进抗利尿激素的释放，而与ＰＧＥ和醛固酮无关。
Understand the anti-diuretic mechanism of suberogorgin (Sub). Methods: The rats were sensitized with water to receive ig Sub3.16 mg · kg-1. Urine was collected and the total urinary excretion of urine was measured by atomic emission spectrometry. Urinary PGE, plasma PGE, ADH and aldosterone were measured by radioimmunoassay. RESULTS: Sub reduced cumulative urinary output and total sodium and potassium levels (up to 91%, 76%, and 86%, respectively) within 24 h after dosing, an effect that diminished over time and Because rats go to the pituitary and almost completely disappeared, but not adrenal influence. Sub 2h post-dose, Sub increased urinary RGE and plasma PGE and ADH concentrations by 25%, 212% and 538%, respectively, without affecting aldosterone levels. CONCLUSIONS: Sub water retention is due to its contribution to the release of antidiuretic hormone, but not to PGE and aldosterone.