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目的研究Caspase-3蛋白在卵巢浆液性肿瘤中的表达水平,探讨其与卵巢浆液性肿瘤临床病理特征的关系,旨在为肿瘤早期诊断、治疗及预后判断提供一个有参考价值的指标。方法应用免疫组化(IHC)和流式细胞术(FCM)检测Caspase-3在卵巢浆液性肿瘤中的表达。统计学分析采用方差分析、t检验。P﹤0.05为差异有统计学意义。结果 Caspase-3蛋白在卵巢浆液性癌中的表达量高于卵巢浆液性囊腺瘤和正常卵巢组织,且与卵巢浆液性癌临床分期、组织分化程度、淋巴结转移无关(P﹥0.05)。结论 Caspase-3蛋白高表达在肿瘤的发生、发展中发挥重要作用,Caspase-3在卵巢浆液性肿瘤中的表达对于鉴别肿瘤的良恶性有一定参考价值。
Objective To study the expression of Caspase-3 protein in ovarian serous tumors and its relationship with clinicopathological features of ovarian serous tumors, and to provide a valuable index for the early diagnosis, treatment and prognosis of tumors. Methods The expression of Caspase-3 in ovarian serous tumors was detected by immunohistochemistry (IHC) and flow cytometry (FCM). Statistical analysis using analysis of variance, t test. P <0.05 for the difference was statistically significant. Results The expression of Caspase-3 protein in ovarian serous carcinoma was higher than that in ovarian serous cystadenoma and normal ovarian tissue, and had no correlation with the clinical stages, histological differentiation and lymph node metastasis (P> 0.05). Conclusion The high expression of Caspase-3 protein plays an important role in the occurrence and development of tumors. The expression of Caspase-3 in ovarian serous tumors has certain reference value for differentiating benign and malignant tumors.