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目的探讨肺癌患者肺部真菌感染的病因、诊断、治疗及预防。方法对50例肺癌合并肺部真菌感染患者的病因、临床表现、治疗等做回顾性分析。结果肺癌患者合并肺部真菌感染与长期应用抗生素、细胞毒性药物以及机体免疫力低下有关。50例肺癌合并肺部真菌感染患者中,25例应用氟康唑,4例应用伊曲霉唑后病情好转,21例并发难以控制的肺部感染而死亡,肺癌并发肺部真菌感染患者病死率为42.0%,明显高于普通细菌感染患者的7.5%。50例的真菌培养均阳性,其中白色念珠菌38例,酵母样菌6例,热带念珠菌6例。结论对于肺癌合并肺部真菌感染的患者应注意早期预防、早期诊断、及时诊治,同时选择合适的抗真菌药物,并提高机体的免疫力及支持治疗,才能达到满意的效果。
Objective To investigate the etiology, diagnosis, treatment and prevention of pulmonary fungal infection in patients with lung cancer. Methods Retrospective analysis was performed on the etiology, clinical manifestations and treatment of 50 cases of lung cancer with pulmonary fungal infection. Results Lung cancer patients with pulmonary fungal infection and long-term use of antibiotics, cytotoxic drugs and low immunity. In 50 cases of lung cancer with pulmonary fungal infection, 25 cases were treated with fluconazole, 4 cases were treated with imatinidazole, the condition improved, 21 cases complicated by uncontrollable pulmonary infection and death, lung cancer with pulmonary fungal infection in patients with mortality was 42.0%, significantly higher than 7.5% of ordinary bacterial infections. 50 cases of fungi were positive, including Candida albicans in 38 cases, yeast-like bacteria in 6 cases, 6 cases of tropical Candida. Conclusion Patients with lung cancer with pulmonary fungal infection should pay attention to early prevention, early diagnosis, timely diagnosis and treatment, while selecting the appropriate antifungal drugs, and improve the body’s immune system and supportive treatment in order to achieve satisfactory results.