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目的探讨乙型肝炎病毒(HBV)宫内感染的高危因素或保护因素。方法对2006年6月至2008年2月在中山大学附属第三医院产科分娩的417例血清HBsAg阳性孕妇的新生儿进行回顾性分析。结果HBV宫内感染组33例,非感染组384例,感染组的母亲HBeAg阳性率、HBV DNA阳性率和非感染组的具有显著性差异(P<0.05),母亲孕晚期注射HBIG在2组中均无显著性差异(P>0.05);在母亲各HBV DNA水平级上分析,新生儿HBV宫内感染和母亲使用HBIG均无明显相关(P>0.05);结论1.HBV DNA阳性是HBV宫内感染的高危因素。2.HBsAg阳性孕妇晚孕期间肌注HBIG对HBV宫内感染未见明显的保护作用。
Objective To investigate the risk factors or protective factors of hepatitis B virus (HBV) intrauterine infection. Methods A retrospective analysis was performed on 417 neonates with HBsAg positive pregnant women who were delivered from the obstetric department of the Third Affiliated Hospital of Sun Yat-sen University from June 2006 to February 2008. Results 33 cases of HBV intrauterine infection group, 384 cases of non-infected group, the mother of the infected group HBeAg positive rate, HBV DNA positive rate and non-infected group had significant difference (P <0.05) (P> 0.05). There was no significant correlation between HBV intrauterine infection in newborns and HBIG in mothers (P> 0.05). Conclusion HBV DNA positive was HBV High risk factors for intrauterine infection. 2. HBsAg-positive pregnant women intramuscular HBIG intrauterine infection during pregnancy no significant protective effect of HBV intrauterine infection.