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冠心病起病急,病死率较高,是严重威胁人类健康的主要疾病之一。长期以来,人们对冠心病的病因、发病机理进行了积极的研究,但至今仍未得出园满的解释。血小板聚集,冠状动脉痉挛已成为近年来冠心病研究的重点课题。尤其具有重要事义的是,Hemberg等1974年发现血小板合成和释放血栓烷(TXA_2),二年后,Moncada又发现血管壁细胞合成前列环素(pGI_2),这两种前列腺素类物质均影响血小板聚集和冠状动脉张力,有可能参与冠心病的发病机理。本文旨在扼要地综述冠状动脉痉挛与冠心病的关系,以及血小板、TXA_2、PGI_2在其中所起的可能作用。
Coronary heart disease acute onset, high mortality, is a serious threat to human health one of the major diseases. For a long time, people have made a positive study on the etiology and pathogenesis of coronary heart disease, but so far they have not yet come to a satisfactory explanation. Platelet aggregation, coronary artery spasm has become the focus of coronary heart disease research in recent years. Of particular importance, Hemberg et al. Found platelet synthesis and TXA2 release in 1974, and two years later Moncada discovered that the angiogenic cells synthesize prostacyclin (pGI_2), both of which affect prostaglandins Platelet aggregation and coronary tension may be involved in the pathogenesis of coronary heart disease. This article aims to briefly summarize the relationship between coronary artery spasm and coronary heart disease, as well as the possible role of platelet, TXA_2 and PGI_2.