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在心血管活动调节中,交感肾上腺素能系统及其介质(儿茶酚胺,特别是去甲肾上腺素)具有重要作用。儿茶酚胺在体内起快速化学调节物的作用,对心脏电的、机械的及代谢的活动发挥主要影响。交感-肾上腺素能系统活性异常提高,不仅与心肌梗塞发病有密切关系,而且是心肌梗塞后伴发心律失常的重要诱因。梗塞心肌cAMP水平升高导致肌膜Na-K-ATP酶(Na-K-泵)活性抑制,胞内K~+外逸,膜电位异常。虽然确切机制尚需进一步研究阐明,但目前已有的研究结果对临床心肌梗塞及并发心律失常的防治工作已经产生了积极作用。
The sympathetic adrenergic system and its mediators (catecholamines, especially norepinephrine) play an important role in the regulation of cardiovascular activity. Catecholamines act as fast chemical regulators in the body and have a major effect on the electrical, mechanical, and metabolic activities of the heart. Sympathetic - adrenergic system activity increased abnormally, not only with the incidence of myocardial infarction is closely related, but also an important cause of arrhythmia after myocardial infarction. Increased cAMP levels in the infarcted myocardium lead to inhibition of Na-K-ATPase (Na-K-ATPase) activity in the myocardium, exocytosis of K ~ +, abnormal membrane potential. Although the exact mechanism needs to be further elucidated, the current research results have had a positive effect on the prevention and treatment of clinical myocardial infarction and concurrent arrhythmia.